Monkeys with six months of alcohol self-administration have disrupted white matter microstructure indicated by decreased fractional anisotropy
Xiaojie Wang 1 , Sarah Plat 1 , Molly McGinnis 1 , Kathleen A Grant 1 , and Christopher D Kroenke 1
Oregon National Primate Research Center,
Oregon Health & Science University, Beaverton, Oregon,
Adult Male and female rhesus monkeys underwent 6 months
of voluntary ethanol drinking following a standard
protocol. DTI measurements were performed prior to
ethanol exposure and following 6 months of alcohol
self-administration. To determine whether white matter
microstructure changes due to voluntary alcohol
drinking, a voxel-wise t-test was performed on white
matter fractional anisotropy (FA) at 6 months and
baseline using tract-based spatial statistics.
Significant FA reductions were detected in frontal white
matter tracts. These results indicate that the
progression of ethanol-induced brain damage observed in
this animal model is consistent with observations made
in studies of human alcoholics.
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