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Abstract #3534

Monkeys with six months of alcohol self-administration have disrupted white matter microstructure indicated by decreased fractional anisotropy

Xiaojie Wang 1 , Sarah Plat 1 , Molly McGinnis 1 , Kathleen A Grant 1 , and Christopher D Kroenke 1

1 Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States

Adult Male and female rhesus monkeys underwent 6 months of voluntary ethanol drinking following a standard protocol. DTI measurements were performed prior to ethanol exposure and following 6 months of alcohol self-administration. To determine whether white matter microstructure changes due to voluntary alcohol drinking, a voxel-wise t-test was performed on white matter fractional anisotropy (FA) at 6 months and baseline using tract-based spatial statistics. Significant FA reductions were detected in frontal white matter tracts. These results indicate that the progression of ethanol-induced brain damage observed in this animal model is consistent with observations made in studies of human alcoholics.

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