Abstract #3536
Treatment Length Effects of Methadone Maintenance on Brain fMRI Response to Cue-elicited Craving in Former Heroin Addicts
Hanyue Wang 1,2 , Yarong Wang 1 , Qiang Li 3 , Dongsheng Zhang 3 , Lina Wang 3 , Jia Zhu 3 , Wei Li 3 , Chongjun Zhang 4 , Jiajie Chen 3 , and Wei Wang 3
1
Radiology, Tangdu Hospital, the Fourth
Military Medical University, Xian, Shan Xi, China,
2
Clinic,
Air Force Equipment Academy, Beijing, Beijing, China,
3
Radiology,
Tangdu Hospital, the Fourth Military Medical University,
Shan Xi, China,
4
Clinic,
Air Force Equipment Academy, Beijing, China
We used functional magnetic resonance imaging(MMT) to
investigate the neural basis of the length effects of
long-term methadone maintenance treatment on brain
response to heroin-related cues in former
heroin-dependent individuals. Fifteen patients (duration
of MMT 1 year, group A) , fifteen matched patients
(duration of MMT 2-3 years, group B) and 17 healthy
controls were included. The self-reported heroin craving
score demonstrated no significant difference between
Group A and B. Compared with Group B, Group A
demonstrated greater activation in caudate when exposed
to drug-related cue. Long-term MMT may improve the brain
craving response by regulating the impaired function of
caudate.
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