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Abstract #3537

Acute Effect of Methadone Maintenance Dose on Cerebral Blood Flow in Heroin Users under Methadone Maintenance Treatment

Chien-Yuan Eddy Lin 1,2 , I-Hsiao Yang 3,4 , Hsiu-Ling Chen 3,4 , Meng-Chang Tsai 5 , Pei-Chin Chen 3,4 , Meng-Hsiang Chen 3,4 , and Wei-Che Lin 3,4

1 GE Healthcare, Taipei, Taiwan, 2 GE Healthcare China, Beijing, China, 3 Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 4 Chang Gung University College of Medicine, Kaohsiung, Taiwan, 5 Department of psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Alteration of cerebral blood flow (CBF) in heroin users under methadone maintenance treatment (MMT) had been reported but the acute effect before and after methadone administration is still less known. The purpose of this study is to investigate the acute changes of CBF in MMT subjects one hour before and after methadone administration by using arterial spin labeling perfusion MRI, and their relationships with history of heroin usage and methadone treatment.

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