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Abstract #3538

Reduction of functional connectivity in adolescents prenatally exposed to alcohol

Bing Ji 1,2 , Zhihao Li 1,3 , Claire Coles 4 , Julie A Kable 4 , Renjie Zhang 2 , and Xiaoping Hu 1

1 Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States, 2 School of Optical Electrical and Computer Engineering, University of Shanghai for Science & Technology, Shanghai, Shanghai, China, 3 Institute of affective and Social Neuroscience, Shenzhen University, Shenzhen, Guangdong, China, 4 Psychiatry and behavioral Science, Emory University, Atlanta, GA, United States

Prenatal alcohol exposure (PAE) is associated with a wide range of cognitive and behavioral deficits. Previous neuroimaging studies of PAE only focused on a few brain regions or neural pathways despite evidences that the teratogenic impact is widespread. The present study examined PAE associated alterations of functional connectivity in 7 brain networks and significant reduction of functional connectivity was observed in 6 of them. The current results support the general hypothesis of PAE associated large-scale network-dysconnectivity thus motivating whole brain connectivity based profiling.

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