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Abstract #3539

Longitudinal changes of functional connectivity with amygdala and prefrontal cortex in adolescents prenatally exposed to cocaine

Zhihao Li 1,2 , Claire Coles 3 , Mary Ellen Lynch 3 , and Xiaoping Hu 1

1 Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States, 2 Institute of Affective and Social Neuroscience, Shenzhen University, Shenzhen, Guangdong, China, 3 Psychiatry and Behavioral Science, Emory University, Atlanta, GA, United States

The present resting-state fMRI study examined the developmental effect of prenatal cocaine exposure (PCE) on functional connectivity in brain networks associated with amygdala (emotion) and left dorsal lateral prefrontal cortex (cognitive functions). The data reflected an improved capacity for stress coping and network segregation in typical development, but this improvement is compromised by PCE. The present results provide further and direct evidence supporting the view of PCE associated long-term effect on arousal regulation.

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