Abstract #3539
Longitudinal changes of functional connectivity with amygdala and prefrontal cortex in adolescents prenatally exposed to cocaine
Zhihao Li 1,2 , Claire Coles 3 , Mary Ellen Lynch 3 , and Xiaoping Hu 1
1
Biomedical Engineering, Emory University &
Georgia Institute of Technology, Atlanta, GA, United
States,
2
Institute
of Affective and Social Neuroscience, Shenzhen
University, Shenzhen, Guangdong, China,
3
Psychiatry
and Behavioral Science, Emory University, Atlanta, GA,
United States
The present resting-state fMRI study examined the
developmental effect of prenatal cocaine exposure (PCE)
on functional connectivity in brain networks associated
with amygdala (emotion) and left dorsal lateral
prefrontal cortex (cognitive functions). The data
reflected an improved capacity for stress coping and
network segregation in typical development, but this
improvement is compromised by PCE. The present results
provide further and direct evidence supporting the view
of PCE associated long-term effect on arousal
regulation.
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