Abstract #3541
Altered brain functional connectivity in MC4R rs12970134 related obesity in young Chinese HAN adults
Baohui Lou 1,2 , Min Chen 1,2 , and Xiaojie Luo 3
1
Graduate School of Peking Union Medical
College, Beijing, Beijing, China,
2
Beijing
Institute of Geriatrics, Beijing Hospital, Beijing,
Beijing, China,
3
Department
of Radiology, Beijing Hospital, Beijing, Beijing, China
This study focused on the rs12970134 near melanocortin 4
receptor (MC4R) gene related structural and functional
alteration of brain in young obese adults from Chinese
HAN population. Voxel-based morphometry analysis of
T1-weighted MRI and functional connectivity (FC)
analysis of resting-state fMRI were adopted. Increased
FC strength between the bilateral hypothalamus and the
regions of food reward and default mode network were
demonstrated in MC4R A-allele carriers in the young
obese adults.
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