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Abstract #3541

Altered brain functional connectivity in MC4R rs12970134 related obesity in young Chinese HAN adults

Baohui Lou 1,2 , Min Chen 1,2 , and Xiaojie Luo 3

1 Graduate School of Peking Union Medical College, Beijing, Beijing, China, 2 Beijing Institute of Geriatrics, Beijing Hospital, Beijing, Beijing, China, 3 Department of Radiology, Beijing Hospital, Beijing, Beijing, China

This study focused on the rs12970134 near melanocortin 4 receptor (MC4R) gene related structural and functional alteration of brain in young obese adults from Chinese HAN population. Voxel-based morphometry analysis of T1-weighted MRI and functional connectivity (FC) analysis of resting-state fMRI were adopted. Increased FC strength between the bilateral hypothalamus and the regions of food reward and default mode network were demonstrated in MC4R A-allele carriers in the young obese adults.

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