Abstract #3542
Mu-opioid receptor related changes in the mouse brain connectome mapped via resting-state functional and diffusion weighted MRI
Anna E Mechling 1,2 , Tanzil Arefin 1,3 , Hsu-Lei Lee 1 , Thomas Bienert 1 , Marco Reisert 1 , Sami Ben Hamida 4 , Jrgen Hennig 1 , Dominik v. Elverfeldt 1 , Brigitte Kieffer 5 , and Laura-Adela Harsan 1
1
Medical Physics, University Medical Center
Freiburg, Freiburg, B-W, Germany,
2
Faculty
of Biology, University of Freiburg, Freiburg, B-W,
Germany,
3
Bernstein
Center for Computational Neuroscience, University of
Freiburg, Freiburg, B-W, Germany,
4
Institut
de Gntique et de Biologie Molculaire et Cellulaire,
Illkirch-Graffenstaden, Alsace, France,
5
Douglas
Research Centre, Montreal, Quebec, Canada
We investigate functional and structural brain
connectivity changes non-invasively via resting-state
functional MRI using BOLD and diffusion weighted MRI
respectively in mu-opioid receptor (MOR) knock-out mice
compared to controls. Our study provides for the first
time a clear link between disrupted MOR function and
whole brain connectome alterations. Remarkable are the
observed remodeling features of networks involving brain
areas that control reward and pain processing. Our
findings reproduce known functions of MOR but also point
towards novel involvement pathways of the receptor
interesting for potential therapeutic compounds for
possible use in psychiatric patients in the future.
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