Meeting Banner
Abstract #3542

Mu-opioid receptor related changes in the mouse brain connectome mapped via resting-state functional and diffusion weighted MRI

Anna E Mechling 1,2 , Tanzil Arefin 1,3 , Hsu-Lei Lee 1 , Thomas Bienert 1 , Marco Reisert 1 , Sami Ben Hamida 4 , Jrgen Hennig 1 , Dominik v. Elverfeldt 1 , Brigitte Kieffer 5 , and Laura-Adela Harsan 1

1 Medical Physics, University Medical Center Freiburg, Freiburg, B-W, Germany, 2 Faculty of Biology, University of Freiburg, Freiburg, B-W, Germany, 3 Bernstein Center for Computational Neuroscience, University of Freiburg, Freiburg, B-W, Germany, 4 Institut de Gntique et de Biologie Molculaire et Cellulaire, Illkirch-Graffenstaden, Alsace, France, 5 Douglas Research Centre, Montreal, Quebec, Canada

We investigate functional and structural brain connectivity changes non-invasively via resting-state functional MRI using BOLD and diffusion weighted MRI respectively in mu-opioid receptor (MOR) knock-out mice compared to controls. Our study provides for the first time a clear link between disrupted MOR function and whole brain connectome alterations. Remarkable are the observed remodeling features of networks involving brain areas that control reward and pain processing. Our findings reproduce known functions of MOR but also point towards novel involvement pathways of the receptor interesting for potential therapeutic compounds for possible use in psychiatric patients in the future.

This abstract and the presentation materials are available to members only; a login is required.

Join Here