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Abstract #3543

Neurobiological Assessment of Stress-Induced Sleep Disturbance in a Rat Model using In Vivo Proton Magnetic Resonance Spectroscopy at 9.4 T: Potential Relevance to Insomnia

Do-Wan Lee 1,2 , Chul-Woong Woo 2 , Sang-Tae Kim 2 , Choong Gon Choi 3 , Bo-Young Choe 1 , and Dong-Cheol Woo 2

1 Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Seoul, Korea, 2 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Seoul, Korea, 3 Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

This study aimed to quantitatively assess the neurobiological changes and responses, after stress-induced sleep disturbance in rats using in vivo proton magnetic resonance spectroscopy (1H-MRS) at 9.4-T. Glu concentrations were significantly lower in hippocampal region of stress-induced-sleep-perturbed rats than in controls (***p=0.004). From our results and previous studies, significantly lower Glu concentrations might reflect an alteration in glutamate turnover in SSP, in comparison to controls, due to excessive glutamatergic neurotransmission driven by neuronal hyperactivity. We determined that significantly lower Glu signals in hippocampus result from stress-induced sleep perturbation, which provides insights into neurochemical alterations and responses associated with psychiatric disorders.

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