Abstract #3543
Neurobiological Assessment of Stress-Induced Sleep Disturbance in a Rat Model using In Vivo Proton Magnetic Resonance Spectroscopy at 9.4 T: Potential Relevance to Insomnia
Do-Wan Lee 1,2 , Chul-Woong Woo 2 , Sang-Tae Kim 2 , Choong Gon Choi 3 , Bo-Young Choe 1 , and Dong-Cheol Woo 2
1
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea College of Medicine, Seoul,
Seoul, Korea,
2
Asan
Institute for Life Sciences, Asan Medical Center, Seoul,
Seoul, Korea,
3
Department
of Radiology, Asan Medical Center, University of Ulsan
College of Medicine, Seoul, Korea
This study aimed to quantitatively assess the
neurobiological changes and responses, after
stress-induced sleep disturbance in rats using in vivo
proton magnetic resonance spectroscopy (1H-MRS) at
9.4-T. Glu concentrations were significantly lower in
hippocampal region of stress-induced-sleep-perturbed
rats than in controls (***p=0.004). From our results and
previous studies, significantly lower Glu concentrations
might reflect an alteration in glutamate turnover in
SSP, in comparison to controls, due to excessive
glutamatergic neurotransmission driven by neuronal
hyperactivity. We determined that significantly lower
Glu signals in hippocampus result from stress-induced
sleep perturbation, which provides insights into
neurochemical alterations and responses associated with
psychiatric disorders.
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