Abstract #3544
Altered regional brain and subjective sleep deficits in chronic primary insomnia:a resting-state fMRI study with ALFF
Xi-Jian Dai 1,2 , Hong-Han Gong 2 , De-Chang Peng 2 , Li Pei 2 , and Yi-Xiang Wang 1
1
Department of Imaging and Interventional
Radiology, Prince of Wales Hospital, The Chinese
University of Hong Kong, Shatin, NT, Hong Kong,
2
Department
of Radiology, The First Affiliated Hospital of Nanchang
University, Nanchang, Jiangxi, China
Despite wide prevalence and broad medical impact,
limited work has been done to investigate
neurobiological mechanisms underlying within a
neuroscientific framework, and still too many disputes
left unclear. In this study, we demonstrated that
chronic primary insomnia does not appear to be
associated with substantial regional spontaneous
activity deficits, and the inability to fall asleep may
be related to a arousal mechanisms to increased activity
in temporal cortex and the interacting neural networks
in the neurobiology of insomnia, including an
emotion-regulating system, a cognitive system and a
visual system. Such changes may decrease arousal
thresholds and/or increase perceptions of wakefulness.
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