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Abstract #3544

Altered regional brain and subjective sleep deficits in chronic primary insomnia:a resting-state fMRI study with ALFF

Xi-Jian Dai 1,2 , Hong-Han Gong 2 , De-Chang Peng 2 , Li Pei 2 , and Yi-Xiang Wang 1

1 Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, 2 Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Despite wide prevalence and broad medical impact, limited work has been done to investigate neurobiological mechanisms underlying within a neuroscientific framework, and still too many disputes left unclear. In this study, we demonstrated that chronic primary insomnia does not appear to be associated with substantial regional spontaneous activity deficits, and the inability to fall asleep may be related to a arousal mechanisms to increased activity in temporal cortex and the interacting neural networks in the neurobiology of insomnia, including an emotion-regulating system, a cognitive system and a visual system. Such changes may decrease arousal thresholds and/or increase perceptions of wakefulness.

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