A multimodal approach to identify and localize complex pathological processes affecting tissue microstructure in Neuropsychiatric SLE
Ece Ercan 1 , Carson Ingo 1 , Cesar Magro Checa 2 , Mark van Buchem 3 , Andrew Webb 1 , and Itamar Ronen 1
C. J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center, Leiden, Netherlands,
of Rheumatology, Leiden University Medical Center,
of Radiology, Leiden University Medical Center, Leiden,
Systemic lupus erythematous (SLE) is an autoimmune
disease affecting multi-organ systems. SLE adversely
impacts the central nervous system, causing neurological
and psychiatric (NP) symptoms in 40% of the patients.
Heterogeneity of NP symptoms among patients and the lack
of gold standard make diagnosis of Neuropsychiatric SLE
(NPSLE) challenging. In this study we applied a
multi-modal approach to better characterize white matter
microstructural damage in NPSLE. Our results suggest
that only a multimodal approach has the potential to
thoroughly identify disease-related changes in the brain
due to complex disease mechanisms such as NPSLE and thus
to improve the clinical diagnosis.
This abstract and the presentation materials are available to members only;
a login is required.