Abstract #3545
A multimodal approach to identify and localize complex pathological processes affecting tissue microstructure in Neuropsychiatric SLE
Ece Ercan 1 , Carson Ingo 1 , Cesar Magro Checa 2 , Mark van Buchem 3 , Andrew Webb 1 , and Itamar Ronen 1
1
C. J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center, Leiden, Netherlands,
2
Department
of Rheumatology, Leiden University Medical Center,
Leiden, Netherlands,
3
Department
of Radiology, Leiden University Medical Center, Leiden,
Netherlands
Systemic lupus erythematous (SLE) is an autoimmune
disease affecting multi-organ systems. SLE adversely
impacts the central nervous system, causing neurological
and psychiatric (NP) symptoms in 40% of the patients.
Heterogeneity of NP symptoms among patients and the lack
of gold standard make diagnosis of Neuropsychiatric SLE
(NPSLE) challenging. In this study we applied a
multi-modal approach to better characterize white matter
microstructural damage in NPSLE. Our results suggest
that only a multimodal approach has the potential to
thoroughly identify disease-related changes in the brain
due to complex disease mechanisms such as NPSLE and thus
to improve the clinical diagnosis.
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