Abstract #3546
1 H MRS Study of Metabolic Alternations in Schizophrenia at 7T
Zhongxu An 1 , Sandeep Ganji 1 , Katherine Borner 1 , Ana Stan 2 , Subroto Ghose 2 , Carol Tamminga 2 , and Changho Choi 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Psychiatry,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States
We report 1H MRS measurement of brain metabolites in
anterior cingulated cortex in schizophrenia patients
versus healthy subjects. 34 schizophrenia patients and
22 age-matched normal subjects were enrolled in the
study. Using previously reported PRESS echo times at 7T,
the signals of GABA, glutamate, and Glycine were
completely resolved from neighboring resonances. Group
analysis indicated significant reduction in glutamate
(p<0.007) and significant increase in glycine (p<0.04)
in schizophrenia. Data showed a trend of reduced GABA in
schizophrenia (p<0.2).
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