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Abstract #3547

Abnormal Bioenergetics in the 1st episode Schizophrenia, Preliminary Studied by the Magnetization Transfer 31P-MRS

Fei Du 1 , Cagri Yuksel 1 , Scott Lukas 1 , Bruce Cohen 1 , and Dost Ongur 1

1 McLean Hospital, Harvard Medical School, Belmont, MA, United States

In vivo probes of cerebral bioenergetics have the capacity to provide crucial information to characterize the exact abnormalities and delineate their relationships with pathophysiology and symptom presentation of schizophrenia. Using novel 31P-MT-MRS and both 1st-episode and chronic patients, our findings indicate schizophrenia may be characterized by an initial active phase of excessive glutamatergic neurotransmission and bioenergetic activity, which then progressively becomes downregulated and result in decreased intracellular pH in the chronic condition. Our findings provide insight into the progression of schizophrenia and highlight the value of using cerebral activity and bioenergetic metabolism as new biomarkers of the pathophysiology of schizophrenia.

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