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Abstract #3549

Enhanced neurometabolic activity and neuroanatomical changes in visual area of rats prenatally exposed to MAM parallel schizophrenic symptoms

Gen Kaneko 1 , Daniel Coman 1 , Basavaraju G Sanganahalli 1 , Helen Wang 1 , Peter Herman 1 , Lihong Jiang 1 , Jyotsna Rao 1 , Stephanie M Groman 2 , Jane R Taylor 2 , Robin A de Graaf 1 , and Fahmeed Hyder 1,3

1 Department of Diagnostic Radiology, Yale University, New Haven, CT, United States, 2 Department of Psychiatry, Yale University, New Haven, CT, United States, 3 Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Visual hallucination is a core positive symptom in schizophrenia associated with increased functional connectivity between visual and hippocampal areas observed by fMRI. We investigated anatomical and metabolic changes in a rat model of schizophrenia (MAM-E17). Compared to controls, MAM rats had thinner visual cortex and higher corpus callosum fractional anisotropy in posterior, but not anterior, regions. In MAM rats neuronal energy metabolism and glutamate-glutamine cycling were both higher in visual cortex, but unchanged in somatosensory cortex. These results suggest that gray/white matter changes and enhanced metabolic activity in the visual pathway may underlie schizophrenic symptoms of visual hallucination.

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