Abstract #3549
Enhanced neurometabolic activity and neuroanatomical changes in visual area of rats prenatally exposed to MAM parallel schizophrenic symptoms
Gen Kaneko 1 , Daniel Coman 1 , Basavaraju G Sanganahalli 1 , Helen Wang 1 , Peter Herman 1 , Lihong Jiang 1 , Jyotsna Rao 1 , Stephanie M Groman 2 , Jane R Taylor 2 , Robin A de Graaf 1 , and Fahmeed Hyder 1,3
1
Department of Diagnostic Radiology, Yale
University, New Haven, CT, United States,
2
Department
of Psychiatry, Yale University, New Haven, CT, United
States,
3
Department
of Biomedical Engineering, Yale University, New Haven,
CT, United States
Visual hallucination is a core positive symptom in
schizophrenia associated with increased functional
connectivity between visual and hippocampal areas
observed by fMRI. We investigated anatomical and
metabolic changes in a rat model of schizophrenia
(MAM-E17). Compared to controls, MAM rats had thinner
visual cortex and higher corpus callosum fractional
anisotropy in posterior, but not anterior, regions. In
MAM rats neuronal energy metabolism and
glutamate-glutamine cycling were both higher in visual
cortex, but unchanged in somatosensory cortex. These
results suggest that gray/white matter changes and
enhanced metabolic activity in the visual pathway may
underlie schizophrenic symptoms of visual hallucination.
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