Abstract #3550
Adolescent olanzapine treated rats cause long term reductions in glutamate and GABA levels in the nucleus accumbens in vivo proton magnetic resonance spectroscopy study
Su Xu 1,2 , Rao P Gullapalli 1,2 , and Douglas O Frost 3,4
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland School of
Medicine, Baltimore, Maryland, United States,
2
Core
for Translational Research in Imaging @ Maryland,
University of Maryland School of Medicine, Baltimore,
Maryland, United States,
3
Department
of Pharmacology, University of Maryland School of
Medicine, Baltimore, Maryland, United States,
4
Department
of Psychiatry, University of Maryland School of
Medicine, Baltimore, Maryland, United States
Olanzapine is a widely prescribed atypical antipsychotic
drug (AAPDs) to treat a variety of psychiatric
disorders. However, little is known about the long-term
effects of olanzapine treatment before the brain is
fully developed. Here, we use
in
vivo
proton
MRS to demonstrate long-term reductions in the levels of
both glutamate and
-aminobutyric
acid in the nucleus accumbens of adult rats treated with
olanzapine during adolescence. The finding is an
essential step for devising new adjunct therapies for
existing AAPDs and for designing new drugs that increase
therapeutic effects and reduce long-term abnormalities
when administered to pediatric patients.
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