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Abstract #3551

Altered cortical microstructure in schizophrenia: a diffusional kurtosis imaging study

Mariana Lazar 1 , Fernando Boada 1 , Laura Miles 1 , Dolores Malaspina 1 , and Oded Gonen 1

1 New York University, New York, New York, United States

In this study we evaluated the gray matter microstructural integrity in schizophrenia using mean kurtosis (MK), a metric of microstructural complexity, obtained using diffusional kurtosis imaging. Seventeen chronic schizophrenia patients and eighteen healthy control participants 30 to 55 years old participated in the study. Increased MK was observed in patients in extended temporal and some prefrontal cortical regions. These findings suggest MK as a promising biomarker of altered gray matter microstructure in schizophrenia. Increased cortical MK was found to associate with inflammatory processes such as astrogliosis. Thus, these findings may bring additional evidence to ongoing inflammation hypotheses in schizophrenia.

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