Altered cortical microstructure in schizophrenia: a diffusional kurtosis imaging study
Mariana Lazar 1 , Fernando Boada 1 , Laura Miles 1 , Dolores Malaspina 1 , and Oded Gonen 1
New York University, New York, New York,
In this study we evaluated the gray matter
microstructural integrity in schizophrenia using mean
kurtosis (MK), a metric of microstructural complexity,
obtained using diffusional kurtosis imaging. Seventeen
chronic schizophrenia patients and eighteen healthy
control participants 30 to 55 years old participated in
the study. Increased MK was observed in patients in
extended temporal and some prefrontal cortical regions.
These findings suggest MK as a promising biomarker of
altered gray matter microstructure in schizophrenia.
Increased cortical MK was found to associate with
inflammatory processes such as astrogliosis. Thus, these
findings may bring additional evidence to ongoing
inflammation hypotheses in schizophrenia.
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