Abstract #3552
Combined prenatal immune activation and peri-pubertal stress alters the neurochemical profile in the mouse cortex but not hippocampus
Alberto Corcoba 1,2 , Sandra Giovanoli 3 , Mirko Schnider 2 , Kim Q. Do 2 , Rolf Gruetter 1,4 , Urs Meyer 3 , and Joao M.N. Duarte 1
1
LIFMET, EPFL, Lausanne, Vaud, Switzerland,
2
Center
for Psychiatric Neuroscience, Department of Psychiatry,
Lausanne University Hospital, Lausanne, Vaud,
Switzerland,
3
Physiology
and Behavior Laboratory, Swiss Federal Institute of
Technology Zurich, Zurich, Zurich, Switzerland,
4
Radiology,
UNIL and UNIGE, Lausanne and Geneva, Vaud and Geneva,
Switzerland
Multiple environmental risk factors, including prenatal
maternal infection and peri-pubertal psychological
stress, potentiate emergency of schizophrenia and
susceptibility for psychopathology. We now demonstrate
that the combination of peri-pubertal stress after
asymptomatic maternal infection leads to development of
neurochemical alterations in the mouse cortex but not
hippocampus.
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