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Abstract #3552

Combined prenatal immune activation and peri-pubertal stress alters the neurochemical profile in the mouse cortex but not hippocampus

Alberto Corcoba 1,2 , Sandra Giovanoli 3 , Mirko Schnider 2 , Kim Q. Do 2 , Rolf Gruetter 1,4 , Urs Meyer 3 , and Joao M.N. Duarte 1

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Vaud, Switzerland, 3 Physiology and Behavior Laboratory, Swiss Federal Institute of Technology Zurich, Zurich, Zurich, Switzerland, 4 Radiology, UNIL and UNIGE, Lausanne and Geneva, Vaud and Geneva, Switzerland

Multiple environmental risk factors, including prenatal maternal infection and peri-pubertal psychological stress, potentiate emergency of schizophrenia and susceptibility for psychopathology. We now demonstrate that the combination of peri-pubertal stress after asymptomatic maternal infection leads to development of neurochemical alterations in the mouse cortex but not hippocampus.

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