Abstract #3553
Reduced Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia
Jun Hua 1,2 , SeungWook Lee 3 , Nicholas I.S. Blair 3 , Allison Brandt 4 , Jaymin Patel 3 , Andreia V. Faria 1 , Issel Anne L. Lim 1,2 , James J. Pekar 1,2 , Peter C. M. van Zijl 1,2 , Christopher A. Ross 4,5 , and Russell L. Margolis 4,5
1
Neurosection, Div. of MRI Research, Dept. of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Department
of Biomedical Engineering, Johns Hopkins University,
Baltimore, Maryland, United States,
4
Department
of Psychiatry and Behavioral Sciences, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
5
Department
of Neurology, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States
Neurovascular alterations have been implicated in the
pathophysiology of schizophrenia. As arterioles are most
responsive to metabolic changes, arteriolar cerebral
blood volume (CBVa) is an important indicator of
cerebrovascular regulation. We show that grey matter
(GM) CBVa, measured with the inflow-based
vascular-space-occupancy (iVASO) MRI technique, is
significantly reduced in schizophrenia patients. The GM
CBVa changes were found in multiple areas across the
whole brain, with the most significant changes in the
frontal and parietal regions. Our results imply that
neurovascular abnormality may play a role in
schizophrenia, and suggest CBVa as a potential surrogate
marker for the disease.
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