Abstract #3554
Enhanced functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T
Jun Hua 1,2 , Nicholas I.S. Blair 3 , Ann Choe 1,2 , Anita Barber 4,5 , Allison Brandt 6 , Issel Anne L. Lim 1,2 , Feng Xu 1,2 , James J. Pekar 1,2 , Peter C. M. van Zijl 1,2 , Christopher A. Ross 4,6 , and Russell L. Margolis 4,6
1
Neurosection, Div. of MRI Research, Dept. of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Department
of Biomedical Engineering, Johns Hopkins University,
Baltimore, Maryland, United States,
4
Department
of Neurology, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States,
5
Department
of Neurology, Kennedy Krieger Institute, Baltimore,
Maryland, United States,
6
Department
of Psychiatry and Behavioral Sciences, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States
The thalamus is a small brain structure that relays
neuronal signals between subcortical and cortical
regions. Abnormal thalamocortical connectivity in
schizophrenia has been documented in previous studies,
which used the entire thalamus as a single node.
Anatomically, the thalamus is subdivided into multiple
distinct nuclei with different connections to various
cortical regions. With the enhanced sensitivity of BOLD
fMRI at 7T, sub-regions in the thalamus defined by a
diffusion based atlas were employed as separate seeds to
calculate whole-brain functional connectivity. Our
results demonstrate widespread changes in
thalamocortical functional connectivity across multiple
brain regions in schizophrenia.
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