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Abstract #3555

Disrupted small-world networks in never treated schizophrenia patients with long illness duration

Li Yao 1 , Wei Deng 2 , Wenjing Zhang 1 , Yuan Xiao 1 , Fei Li 1 , Jieke Liu 1 , John A Sweeney 3 , Qiyong Gong 1 , and Su Lui 1

1 Huaxi MR Research Center, Chengdu, Sichuan, China, 2 Department of Psychiatry, Stat Key Lab of Biotherapy, West China Hospital of Sichuan University, Sichuan, China, 3 UT Southwestern Medical Center, Texas, United States

Using graph theory-based approaches,we explored whether there are different age-related brain functional change patterns in chronic but never treated schizophrenia patients than healthy controls. Our findings revealed altered global topological organization toward regularization and decreased nodal centralities in amygdala, olfactory, precuneus and putamen in later phase of schizophrenia without the potential confounding of antipsychotic treatment. Specifically, the age-related disruptions in amygdala suggested this region might act as an important component in the physiopathologic evolution of long-term schizophrenia.

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