Abstract #3555
Disrupted small-world networks in never treated schizophrenia patients with long illness duration
Li Yao 1 , Wei Deng 2 , Wenjing Zhang 1 , Yuan Xiao 1 , Fei Li 1 , Jieke Liu 1 , John A Sweeney 3 , Qiyong Gong 1 , and Su Lui 1
1
Huaxi MR Research Center, Chengdu, Sichuan,
China,
2
Department
of Psychiatry, Stat Key Lab of Biotherapy, West China
Hospital of Sichuan University, Sichuan, China,
3
UT
Southwestern Medical Center, Texas, United States
Using graph theory-based approaches,we explored whether
there are different age-related brain functional change
patterns in chronic but never treated schizophrenia
patients than healthy controls. Our findings revealed
altered global topological organization toward
regularization and decreased nodal centralities in
amygdala, olfactory, precuneus and putamen in later
phase of schizophrenia without the potential confounding
of antipsychotic treatment. Specifically, the
age-related disruptions in amygdala suggested this
region might act as an important component in the
physiopathologic evolution of long-term schizophrenia.
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