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Abstract #3560

Elevated Levels of Myo-inositol and Choline in the Associative Striatum of Antipsychotic-Nave Patients with First Episode Psychosis

Eric Plitman 1,2 , Camilo de la Fuente-Sandoval 3 , Pablo Len-Ortiz 3 , Francisco Reyes-Madrigal 3 , Gladys Gmez-Cruz 3 , Shinichiro Nakajima 1,4 , Philip Gerretsen 1,5 , M Mallar Chakravarty 6,7 , Sofia Chavez 1,5 , Jun Ku Chung 1,2 , Fernando Caravaggio 1,2 , Yusuke Iwata 1,4 , Danielle Uy 1 , Gary Remington 1,5 , and Ariel Graff-Guerrero 1,5

1 Centre for Addiction and Mental Health, Toronto, Ontario, Canada, 2 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 3 Instituto Nacional de Neurologa y Neurociruga, Mexico, 4 Neuropsychiatry, Keio University School of Medicine, Japan, 5 Psychiatry, University of Toronto, Toronto, Ontario, Canada, 6 Douglas Mental Health University Institute, Montreal, Quebec, Canada, 7 Psychiatry, McGill University, Montreal, Quebec, Canada

The degree to which myo-inositol (mI) and choline compounds (Cho) are disrupted in patients with schizophrenia is unclear. Proton magnetic resonance spectroscopy was used to compare mI and Cho levels in the associative striatum between antipsychotic-nave patients experiencing their first non-affective psychosis episode and a matched group of healthy controls. Patients clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). mI and Cho were elevated in the patient group. mI was associated with PANSS Positive total, P3 (Hallucinatory Behaviour), and P5 (Grandiosity) scores. The concomitant elevation of mI and Cho supports early glial cell disruption in schizophrenia.

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