Abstract #3560
Elevated Levels of Myo-inositol and Choline in the Associative Striatum of Antipsychotic-Nave Patients with First Episode Psychosis
Eric Plitman 1,2 , Camilo de la Fuente-Sandoval 3 , Pablo Len-Ortiz 3 , Francisco Reyes-Madrigal 3 , Gladys Gmez-Cruz 3 , Shinichiro Nakajima 1,4 , Philip Gerretsen 1,5 , M Mallar Chakravarty 6,7 , Sofia Chavez 1,5 , Jun Ku Chung 1,2 , Fernando Caravaggio 1,2 , Yusuke Iwata 1,4 , Danielle Uy 1 , Gary Remington 1,5 , and Ariel Graff-Guerrero 1,5
1
Centre for Addiction and Mental Health,
Toronto, Ontario, Canada,
2
Institute
of Medical Science, University of Toronto, Toronto,
Ontario, Canada,
3
Instituto
Nacional de Neurologa y Neurociruga, Mexico,
4
Neuropsychiatry,
Keio University School of Medicine, Japan,
5
Psychiatry,
University of Toronto, Toronto, Ontario, Canada,
6
Douglas
Mental Health University Institute, Montreal, Quebec,
Canada,
7
Psychiatry,
McGill University, Montreal, Quebec, Canada
The degree to which myo-inositol (mI) and choline
compounds (Cho) are disrupted in patients with
schizophrenia is unclear. Proton magnetic resonance
spectroscopy was used to compare mI and Cho levels in
the associative striatum between antipsychotic-nave
patients experiencing their first non-affective
psychosis episode and a matched group of healthy
controls. Patients clinical symptoms were assessed
using the Positive and Negative Syndrome Scale (PANSS).
mI and Cho were elevated in the patient group. mI was
associated with PANSS Positive total, P3 (Hallucinatory
Behaviour), and P5 (Grandiosity) scores. The concomitant
elevation of mI and Cho supports early glial cell
disruption in schizophrenia.
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