Meeting Banner
Abstract #3559

Widespread decrease of fractional anisotropy in never treated schizophrenia patients with disease duration over 5 years

Yuan Xiao 1 , Wei Deng 2 , Huaiqiang Sun 1 , Wenjing Zhang 1 , Li Yao 1 , Jia Liu 1 , Min Wu 1 , Chandan Shah 1 , Qiyong Gong 1 , and Su Lui 1

1 Department of Radiology, West China Hospital of Sichuan University, Huaxi Magnetic Resonance Research Ctr., Chengdu, Sichuan, China, 2 Department of Psychiatry, State Key Laboratory of Biotherapy, Chengdu, Sichuan, China

Tract-based spatial statistics was employed to investigate the white matter microstructure alteration in a rare case of chronic but never-medicated schizophrenia patients. 26 patients and 28 healthy controls were recruited in this study. It revealed widespread decrease of FA in the patients, especially in anterior thalamic radiation, corticospinal tract, cingulum (cingulate gyrus), forceps minor, inferior fronto-occipital fasciculus and superior longitudinal fasciculus. However, only forceps minor exhibited faster aging effect than controls suggesting the critical role of forceps minor in the progressive mechanism of schizophrenia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here