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Abstract #3558

Acute Impact of Antipsychotic Treatment on Patient with Schizophrenia: A tract-based automatic analysis (TBAA) with diffusion spectrum imaging (DSI).

Su-Chun Huang 1 , Chih-Min Liu 2 , Tzung-Jeng Hwang 2 , Hai-Gwo Hwu 2 , Yung-Chin Hsu 1 , Yu-Chun Lo 1 , Yu-Jen Chen 1 , and Wen-Yih Isaac Tseng 1,3

1 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, 2 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, 3 Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

In the present study we found that after 4 weeks of treatment, GFA value was significantly increased in left SLF II, SLF III, and ML. The increase was not presented along the whole tract, but limited to discrete segments. Since all the patients reported reduced severity of symptoms after treatments, these results suggest that the medication can modulate the integrity of white matter tract, and further influence the clinical symptoms. Notably, all the differences were found in tracts related of sensory input and integration, implying that the core pathology of schizophrenia may be related to sensory integration

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