Abstract #3557
Effects of DISC1 genes on clinical symptoms and thalamic radiation in patients with schizophrenia: A tract-based diffusion spectrum imaging analysis
Hsu-Hwa Tseng 1,2 , Su-Chun Huang 2 , Chih-Min Liu 3 , Tzung-Jeng Hwang 3 , Hai-Gwo Hwu 3 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Yu-Jen Chen 2 , and Wen-Yih Isaac Tseng 2
1
School of Medicine, College of Medicine,
National Taiwan University, Taipei, Taiwan,
2
Center
for Optoelectronic Biomedicine, National Taiwan
University College of Medicine, Taipei, Taiwan,
3
Department
of Psychiatry, National Taiwan University Hospital,
Taipei, Taiwan
DISC1 gene influences the severity of the clinical
symptoms of individuals with SZ. Higher PANSS scores in
some specific subscales could be predicted in
individuals with risk forms. Besides, DISC1 gene
influences the white matter properties of thalamic
radiation. Since all the subjects were medicated, we
speculate that the negative correlations between the
symptoms and the white matter properties might reflect
in part the treatment effects. Individuals with the
protective form of DISC1-27 seem to have a better
treatment effect on negative symptoms.
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