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Abstract #3557

Effects of DISC1 genes on clinical symptoms and thalamic radiation in patients with schizophrenia: A tract-based diffusion spectrum imaging analysis

Hsu-Hwa Tseng 1,2 , Su-Chun Huang 2 , Chih-Min Liu 3 , Tzung-Jeng Hwang 3 , Hai-Gwo Hwu 3 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Yu-Jen Chen 2 , and Wen-Yih Isaac Tseng 2

1 School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 2 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, 3 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan

DISC1 gene influences the severity of the clinical symptoms of individuals with SZ. Higher PANSS scores in some specific subscales could be predicted in individuals with risk forms. Besides, DISC1 gene influences the white matter properties of thalamic radiation. Since all the subjects were medicated, we speculate that the negative correlations between the symptoms and the white matter properties might reflect in part the treatment effects. Individuals with the protective form of DISC1-27 seem to have a better treatment effect on negative symptoms.

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