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Abstract #3562

Lower Glutathione Levels in the Anterior Cingulate Cortex of Patients with Schizophrenia: A preliminary 3T 1H-MRS Study

Napapon Sailasuta 1 , Yusuke Iwata 1 , Shinichiro Nakajima 1 , Sofia Chavez 1 , Fernando Caravaggio 1 , Eric Plitman 1 , Vincenzo De Luca 1 , Jun Ku Chung 1 , Philip Gerretsen 1 , Gary Remington 1 , and Ariel Graff-Guerrero 1

1 The Centre for Addiction and Mental Health, toronto, ON, Canada

Our current stuty is aimed to compare Glutathione (GSH) levels between in patients with Schizophrenia (Sz) and healty controls (HC) quantified in the ACC employing a validated J-editing quantification method.GSH levels were quantified with 1H-MRS. Our pilot data demonstrated lower levels of GSH/H2O in ACC in patients with Sz compared with HC (P= 0.0002).

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