Meeting Banner
Abstract #3563

Lateralization of Glx and GABA metabolic changes in anterior cingulate for Ultra High Risk Schizophrenia patients.

Petr Menschikov 1 , Natalia Semenova 1,2 , Maxim Ublinskii 3 , Dmitry Kupriyanov 4 , Irina Lebedeva 5 , Maria Omelchenko 5 , and Tolibjon Akhadov 3

1 N.N. Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, 2 N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, 3 Children's Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russian Federation, 4 Philips Healthcare Russia, Moscow, Russian Federation, 5 National Mental Health Research Centre of the Russian Academy of Medical Sciences, Moscow, Russian Federation

It was reported previously that GLX is reduced in anterior cingulate (AC) for chronic schizophrenia patients medicated with antipsychotic drugs. Reduction of GLX in right hemisphere in our study reflects changes in the metabolic system as a consequence of the illness itself, without influence of treatment with antipsychotics or age changes. We assume also that left AC GABA reduction observed in our study is typical for schizophrenia development - previously reported unchanged GABA in AC of young chronic medicated patients could be associated with an effect of antipsychotic medication.

This abstract and the presentation materials are available to members only; a login is required.

Join Here