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Abstract #3570

Hypertension Induced Change of Retina and Optic Tract in SHR

Qian Wang 1,2 , Yunxia Li 1,3 , Eric R Muir 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1

1 Research Imaging Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Xiang Ya School of Medicine, Central South University, Changsha, China, 3 Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China

The goal of this study was to investigate the effects of hypertension on the optic tract and retinal nerve fiber layer thickness in the established rat model of hypertension (SHR). Comparisons were made with age-matched normotensive Wistar Kyoto (WKY) rats. In conclusion, we found evidence that chronic hypertension damage white matter in the optic tract (as indicated by FA disruption and immunohistology) and retina (as indicated by retinal nerve fiber layer and vascular diameter changes) in an established animal model of hypertension.

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