Abstract #3570
Hypertension Induced Change of Retina and Optic Tract in SHR
Qian Wang 1,2 , Yunxia Li 1,3 , Eric R Muir 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1
1
Research Imaging Institute, The University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States,
2
Xiang
Ya School of Medicine, Central South University,
Changsha, China,
3
Department
of Neurology, Tongji Hospital, Tongji University,
Shanghai, China
The goal of this study was to investigate the effects of
hypertension on the optic tract and retinal nerve fiber
layer thickness in the established rat model of
hypertension (SHR). Comparisons were made with
age-matched normotensive Wistar Kyoto (WKY) rats. In
conclusion, we found evidence that chronic hypertension
damage white matter in the optic tract (as indicated by
FA disruption and immunohistology) and retina (as
indicated by retinal nerve fiber layer and vascular
diameter changes) in an established animal model of
hypertension.
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