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Abstract #3571

Task-dependent neurovascular uncoupling in Moyamoya disease

Erin L Mazerolle 1 , Yuhan Ma 2 , David Sinclair 2 , and G Bruce Pike 1

1 University of Calgary, Calgary, Alberta, Canada, 2 McGill University, Montreal, Quebec, Canada

We investigated task-related hemodynamics in moyamoya disease (MMD). Patients with MMD exhibit abnormal cerebrovascular reactivity in anterior brain regions, which we predicted would be associated with neurovascular uncoupling. We compared BOLD fMRI activation maps among tasks with varying extents of associated vascular demands. For tasks associated with extensive vascular demands, we found atypically low activation in MMD-affected brain regions, reflective of neurovascular uncoupling. This activation could be partially or completely recovered when the total extent of the tasks vascular demands was reduced. Thus, the potential effects of neurovascular uncoupling must be considered in patients with cerebrovascular disease.

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