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Abstract #3573

To study chronic hypobaric hypoxia induced metabolic alteration in rat brain using high resolution NMR spectroscopy

Sunil Koundal 1,2 , Sonia Gandhi 1 , Tanzeer kaur 2 , and Subash Khushu 1

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, Delhi, India, 2 Department of Biophysics, Panjab University, Chandigarh, India

Chronic hypobaric hypoxia induced metabolic alterations in brain hippocampus was studied using high resolution 600MHz NMR spectrometer. The alterations in metabolites may have altered due to change in neuronal structure, altered cellular bioenergetics and osmolarity. Further, our results can be correlated with in vivo and behavioral studies to detect if these alterations have effect on memory functions of brain for risk assessment & early diagnosis.

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