To study chronic hypobaric hypoxia induced metabolic alteration in rat brain using high resolution NMR spectroscopy
Sunil Koundal 1,2 , Sonia Gandhi 1 , Tanzeer kaur 2 , and Subash Khushu 1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences (INMAS), New Delhi, Delhi,
of Biophysics, Panjab University, Chandigarh, India
Chronic hypobaric hypoxia induced metabolic alterations
in brain hippocampus was studied using high resolution
600MHz NMR spectrometer. The alterations in metabolites
may have altered due to change in neuronal structure,
altered cellular bioenergetics and osmolarity. Further,
our results can be correlated with in vivo and
behavioral studies to detect if these alterations have
effect on memory functions of brain for risk assessment
& early diagnosis.
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