Abstract #3576
Transgenic mouse model recapitulates brain pathophysiology of sickle cell disease
Lisa M Gazdzinski 1 , Lindsay S Cahill 1 , Yu-Qing Zhou 1 , Albert KY Tsui 2,3 , Gregory MT Hare 2,3 , Andrea Kassner 4,5 , and John G Sled 1,6
1
Mouse Imaging Centre, Hospital for Sick
Children, Toronto, Ontario, Canada,
2
Department
of Anaesthesia, St. Michael's Hospital, Toronto,
Ontario, Canada,
3
Keenan Research Centre for
Biomedical Science, University of Toronto, Ontario,
Canada,
4
Department
of Medical Imaging, University of Toronto, Ontario,
Canada,
5
Department of Physiology and
Experimental Medicine, Hospital for Sick Children,
Toronto, Ontario, Canada,
6
Department
of Medical Biophysics, University of Toronto, Ontario,
Canada
Sickle cell disease (SCD) is associated with
neurocognitive impairment and an increased risk of
stroke. The mechanisms are poorly understood, but likely
involve increased cerebral blood flow (CBF) and
decreased cerebrovascular reserve (CVR). This study uses
CASL to characterize CBF and CVR in a transgenic mouse
model of SCD, demontrating that the model recapitulates
important pathophysiological features of the disease.
Brain morphometry is also performed using
high-resolution MRI, showing localized volume
differences throughout the brain in SCD mice. The model
characterized here will be invaluable for developing an
understanding of the mechanisms behind stroke and
neurocognitive impairment in SCD.
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