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Abstract #3578

A study on brain-behaviour functional relations in areas affected due to ischemic stroke using diffusion MRI

J. Mitra 1 , P. Bourgeat 1 , J. Fripp 1 , O. Salvado 1 , B. Campbell 2 , S. Palmer 3 , P. Goodin 3 , A. Connelly 3,4 , S. Rose 1 , L. Carey 3,4 , and the START Program Team 5

1 Australian e-Health & Research Centre, CSIRO Digital Productivity Flagship, Herston, QLD, Australia, 2 Department of Radiology, The Melbourne Brain Centre at the Royal Melbourne Hospital, VIC, Australia, 3 The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia, 4 La Trobe University, Bundoora, VIC, Australia, 5, VIC, Australia

Cerebral white matter is especially vulnerable to hypoxic-ischemic injury, resulting in white matter lesions. Knowledge of how brain networks are interrupted is currently limited, but critical to better understanding the nature of the clinical deficit and stroke recovery. We used diffusion-weighted MRI and probabilistic tractography to identify the common neural pathways affected in stroke patients, with a view of predicting cognitive and functional deficits associated with the affected areas. Our hypothesis is that loss in connectivity in these common regions will correlate with the clinical measurements of cognition, sensorimotor function and disability.

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