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Abstract #3582

Characterization of carotid plaque composition using ex-vivo Magnetic Resonance Imaging at 7T and histopathology

Rosario Lopez-Gonzalez 1 , Sin Yee Foo 2 , William M Holmes 3 , William Stewart 4 , Keith Muir 5 , Barrie Condon 6 , George Welch 7 , and Kirsten Forbes 8

1 Clinical Physics and Bioengineering, NHS, Glasgow, Glasgow, United Kingdom, 2 School of Medicine, University of Glasgow, Glasgow, United Kingdom, 3 GEMRIC, Institute of Neuroscience and Psychology, Glasgow, United Kingdom, 4 Neuropathology, NHS, Glasgow, United Kingdom, 5 Division of Clinical Neurosciences, University of Glasgow, Glasgow, United Kingdom, 6 NHS, Glasgow, United Kingdom, 7 Vascular Surgery, NHS, Glasgow, United Kingdom, 8 Institute of Neurological Sciences, NHS, Glasgow, United Kingdom

This study aims to evaluate the ability to identify all major carotid plaque components using ex-vivo 7T MRI and correlation with histology. Surgical excision of atherosclerotic carotid plaque (carotid endarterectomy, CEA), based on the extent of luminal narrowing, reduces risk of subsequent stroke. However, 70% of patients with severe stenosis remain stroke-free over the next 5 years with medical therapy alone. Outcomes from CEA could be improved by targeting treatment at high-risk subgroups. Atherosclerotic plaque morphology and plaque composition may identify unstable or vulnerable plaque that defines higher risk.

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