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Abstract #3581

Aberrant regional homogeneity related to cognitive impairment in subcortical stroke patients: A resting-state fMRI study

Cheng-Yu Peng 1 , Ying Cui 1 , Deng-Ling Zhao 1 , Yun Jiao 1 , Shenghong Ju 1 , and Gao-Jun Teng 1

1 Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospita, Nanjing, Jiangsu, China

A stroke can increase the risk of vascular cognitive impairment. This study utilised resting-state fMRI to investigate regional homogeneity (ReHo) changes in subcortical stroke patients and whether these changes were correlated with cognitive performance. The stroke patients exhibited significant deficiencies in relevant cognitive domains and also demonstrated significantly aberrant ReHo values in some specific brain regions compared with the healthy controls. Moreover, the ReHo values of the right superior temporal gyrus/middle temporal gyrus were significantly correlated with the cognitive test scores in the stroke group. ReHo could represent a promising tool for the observation of neurobiological consequences in post-stroke patients.

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