Abstract #3590
Correlation of Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations with Clinical Features
Huan Tan 1 , Abdul Ghani Mikati 1 , Lingjiao Zhang 1 , Tian Liu 2 , Yi Wang 3 , Robert R Edelman 4,5 , Gregory A. Christoforidis 1 , and Issam A. Awad 1
1
Surgery, University of Chicago, Chicago, IL,
United States,
2
MedImageMetric
LLC, New York, NY, United States,
3
Weill
Cornell Medical College, New York, NY, United States,
4
NorthShore
University HealthSystem, Evanston, IL, United States,
5
Northwestern
University Feinberg School of Medicine, Chicago, IL,
United States
We have previously demonstrated the feasibility of using
quantitative susceptibility mapping (QSM) for lesional
iron quantification in patients with cerebral cavernous
malformations (CCM). In this study, we correlated mean
susceptibility measurements with patients clinical
activities and we found: 1) older lesions harbor more
iron deposition; 2) lesions that has bled previously
contain more iron deposition; 3) longitudinal changes in
lesional iron deposition were small in patients who are
clinically stable in a short time frame (<1.5 years).
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