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Abstract #3590

Correlation of Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations with Clinical Features

Huan Tan 1 , Abdul Ghani Mikati 1 , Lingjiao Zhang 1 , Tian Liu 2 , Yi Wang 3 , Robert R Edelman 4,5 , Gregory A. Christoforidis 1 , and Issam A. Awad 1

1 Surgery, University of Chicago, Chicago, IL, United States, 2 MedImageMetric LLC, New York, NY, United States, 3 Weill Cornell Medical College, New York, NY, United States, 4 NorthShore University HealthSystem, Evanston, IL, United States, 5 Northwestern University Feinberg School of Medicine, Chicago, IL, United States

We have previously demonstrated the feasibility of using quantitative susceptibility mapping (QSM) for lesional iron quantification in patients with cerebral cavernous malformations (CCM). In this study, we correlated mean susceptibility measurements with patients clinical activities and we found: 1) older lesions harbor more iron deposition; 2) lesions that has bled previously contain more iron deposition; 3) longitudinal changes in lesional iron deposition were small in patients who are clinically stable in a short time frame (<1.5 years).

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