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Abstract #3591

Exercise Intensity Modulates the Change in Cerebral Blood Flow Following Aerobic Exercise in Chronic Stroke: a PCASL Study

Andrew D. Robertson 1 , David E. Crane 1 , A. Saeed Rajab 1,2 , Walter Swardfager 1,3 , Susan Marzolini 1,3 , Laura E. Middleton 3,4 , and Bradley J. MacIntosh 1,2

1 Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3 Toronto Rehabilitation Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 4 University of Waterloo, Department of Kinesiology, Waterloo, ON, Canada

We examined how exercise intensity affects cerebral blood flow (CBF) following acute cycling in stroke. Using arterial spin labeling, CBF estimates were made before, 30 min after, and 50 min after exercise. Participants exercised at low and moderate intensities on separate days. CBF was changed after cycling, independent of intensity, in areas within the right basal ganglia and frontal lobe, and left temporal and parietal lobes. The right parietal lobe, in particular, was sensitive to intensity. In three areas, CBF increased after moderate intensity cycling, relative to light exercise. Parietal regions may provide a sensitive biomarker for exercise-based stroke rehabilitation.

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