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Abstract #3602

The alterations of functional brain network and its relationship to cognitive decline in patients with carotid stenosis: a resting-state fMRI study

Pei-Shan Ho 1,2 , Ting-Yu Chang 3 , Meng-Yang Ho 4 , Chang-Wei Wu 5 , Kuo-Lun Huang 3 , Ho-Fai Wong 6 , Tsong-Hai Lee 3 , and Ho-Ling Liu 1,7

1 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, 3 Department of Neurology and Stroke Center, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan, 4 Department of Occupational Therapy, Chang Gung University, Taoyuan, Taiwan, 5 Graduate Institute of Biomedical Engineering, National Central University, Taoyuan, Taiwan, 6 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 7 Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States

Severe internal carotid artery (ICA) stenosis impairs brain cognitive function, which might be originated from cerebral hypoperfusion. However, the underlying brain mechanisms remain largely unknown. This study aimed at investigating the relationship of brain functional connectivity and neuropsychology in both unilateral ICA stenotic patients (N=27) and normal subjects (N=20). We compared indicative network parameters between ICA stenotic patients and normal subjects across two hemispheres. We found lower degree and global efficiency in the ipsilateral side to the stenosis. Moreover, network parameters were positively correlated with neuropsychological tests in the patients. Our results implied that the patients with more deteriorated brain.

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