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Abstract #3603

Hybridized arterial spin labeled MR angiography in the evaluation of carotid artery stenosis in patients with suspected stroke: Preliminary analysis and comparison to gadolinium-enhanced MR angiography

Kai Xu 1 , LeRoy Stromberg 1 , David Rusinak 1 , Stephen Futterer 1 , Shivraman Giri 1 , James Carr 1 , Robert Edelman 1 , Ioannis Koktzoglou 2 , and Jeremy Collins 1

1 Radiology, Northwestern University, Chicago, IL, United States, 2 Radiology, NorthShore University HealthSystem, Evanston, IL, United States

Carotid artery atherosclerosis is an important etiology of stroke, for which morphological assessment with quantitation of luminal narrowing plays a critical role in diagnosis and mangement. However, contrast-enhanced MRA and contrast-enhanced CTA are contraindicated in patients with stage 4 or 5 renal insufficiency due to the risk of nephrogenic systemic fibrosis and iodinated contrast induced nephropathy. hASL is a non-contrast MR angiographic technique which has shown promise for neurovascular assessment. In a prospective patient cohort with suspected stroke, hASL MRA excluded carotid artery stenosis as an etiology, demonstrating excellent agreement with contrast-enhanced MRA.

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