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Abstract #3612

The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-defined Normal Tissue, Ischemic Penumbra and Ischemic Core

Zhao Jiang 1 , Lora Talley Watts 1 , Shiliang Huang 1 , Pavel Rodriguez 1 , Qiang Shen 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Methylene blue (MB) USP, which has energy-enhancing and antioxidant properties, is currently used to treat methemoglobinemia and cyanide poisoning in humans. We recently showed that MB administration reduces infarct volume and behavioral deficits in rat models of ischemic stroke and traumatic brain injury. This study reports the underlying molecular mechanisms of MB neuroprotection following transient ischemic stroke in rats.

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