Abstract #3613
pH-weighted imaging in diabetes mellitus suffering acute cerebral ischemic stroke
Zhuozhi Dai 1,2 , Yanlong Jia 2 , Gen Yan 2 , Fei Duan 2 , Gang Xiao 3 , Zhiwei Shen 4 , Hongfu Sun 1 , Alan H. Wilman 1 , and Renhua Wu 2,4
1
Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada,
2
Medical
Imaging, 2nd Affiliated Hospital, Shantou University
Medical College, Shantou, Guangdong, China,
3
Math
and Information Technology, Hanshan Normal University,
Guangdong, China,
4
Provincial
Key Laboratory of Medical Molecular Imaging, Guangdong,
China
The presence of diabetes increases the risk and severity
of stroke, but conventional MRI examinations cannot
distinguish between diabetic and non-diabetic stroke. To
our knowledge this is the first report on pH-weighted
imaging in diabetic stroke models. We obtained a
significant pH decrease in the ischemic lesion in
diabetes compared with non-diabetes in vivo, which may
provide a marker of specificity of diabetic stroke.
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