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Abstract #3613

pH-weighted imaging in diabetes mellitus suffering acute cerebral ischemic stroke

Zhuozhi Dai 1,2 , Yanlong Jia 2 , Gen Yan 2 , Fei Duan 2 , Gang Xiao 3 , Zhiwei Shen 4 , Hongfu Sun 1 , Alan H. Wilman 1 , and Renhua Wu 2,4

1 Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, 2 Medical Imaging, 2nd Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China, 3 Math and Information Technology, Hanshan Normal University, Guangdong, China, 4 Provincial Key Laboratory of Medical Molecular Imaging, Guangdong, China

The presence of diabetes increases the risk and severity of stroke, but conventional MRI examinations cannot distinguish between diabetic and non-diabetic stroke. To our knowledge this is the first report on pH-weighted imaging in diabetic stroke models. We obtained a significant pH decrease in the ischemic lesion in diabetes compared with non-diabetes in vivo, which may provide a marker of specificity of diabetic stroke.

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