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Abstract #3616

Compromised cerebrovascular reactivity is reversible in patients with carotid artery stenosis: A BOLD MRI study

Jian Hui-Shan 1,2 , Chang Ting-Yu 1 , Huang Kuo-Lun 1 , Chang Yeu-Jhy 1 , Chang Chien-Hung 1 , Wai Yau-Yau 3 , Yeh Chih-Hua 3 , Lee Tsong-Hai 1 , and Liu Ho-Ling 4,5

1 Department of Neurology and Stroke Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2 Departiment of Biomedical Engineering and Environmental Sciences, Tsing Hua University, Hsinchu, Taiwan, 3 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 4 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 5 Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States

We investigated whether the impaired cerebrovascular reactivity dynamics in patients with unilateral ICA stenosis is reversible after carotid artery stenting (CAS). Ten subjects underwent dynamic BOLD MRI during repeated breath-holding, before and after stenting, on a 3T scanner. Signal time courses from the MCA territory were extracted for each hemisphere for evaluation. We found that the ipsilateral MCA time course was significantly compromised, presenting as smaller amplitude, wider response and delayed onset, as compared to the contralateral one before CAS (p<0.05). This phenomenon was recovered after CAS, demonstrating significantly improved correlation between BOLD responses obtained from the two hemispheres (p<0.001).

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