Abstract #3617
GRE vs. PWI for Hemorrhage and Intravascular Clot Detection: A Retrospective Analysis of the DEFUSE2, EPITHET and SENSE 3 Datasets
Shalini A. Amukotuwa 1,2 , Fernando Calamante 2 , Stephen M. Davis 3 , Gregory W. Albers 4 , and Roland Bammer 1,5
1
Department of Radiology, Stanford
University, Stanford, CA, United States,
2
The
Florey Institute of Neuroscience and Mental Health,
University of Melbourne, Parkville, VIC, Australia,
3
Department
of Neurology, Royal Melbourne Hospital, Parkville, VIC,
Australia,
4
Department
of Neurology, Stanford University, Stanford, CA, United
States,
5
on
behalf of the EPITHET, DEFUSE2, and SENSE3
investigators, United States
In acute stroke patients, detection of acute hemorrhage
is critical, but must be balanced against the need for
fast imaging (as treatment is time-critical).
Unfortunately, conventional T2*-weighted gradient-echo
(GRE) sequences, the mainstay of hemorrhage detection on
MRI, are time consuming. We have investigated and found
that DSC-EPI-based PWI has a high sensitivity and
specificity for the detection of acute hemorrhage, and
hemorrhagic transformation of acute stroke in
particular, and is superior to GRE for the detection of
intra-arterial thrombus. Therefore, DSC EPI based PWI is
likely sufficient for hemorrhage detection, allowing GRE
to be omitted from the acute stroke protocol.
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