Meeting Banner
Abstract #3617

GRE vs. PWI for Hemorrhage and Intravascular Clot Detection: A Retrospective Analysis of the DEFUSE2, EPITHET and SENSE 3 Datasets

Shalini A. Amukotuwa 1,2 , Fernando Calamante 2 , Stephen M. Davis 3 , Gregory W. Albers 4 , and Roland Bammer 1,5

1 Department of Radiology, Stanford University, Stanford, CA, United States, 2 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia, 3 Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia, 4 Department of Neurology, Stanford University, Stanford, CA, United States, 5 on behalf of the EPITHET, DEFUSE2, and SENSE3 investigators, United States

In acute stroke patients, detection of acute hemorrhage is critical, but must be balanced against the need for fast imaging (as treatment is time-critical). Unfortunately, conventional T2*-weighted gradient-echo (GRE) sequences, the mainstay of hemorrhage detection on MRI, are time consuming. We have investigated and found that DSC-EPI-based PWI has a high sensitivity and specificity for the detection of acute hemorrhage, and hemorrhagic transformation of acute stroke in particular, and is superior to GRE for the detection of intra-arterial thrombus. Therefore, DSC EPI based PWI is likely sufficient for hemorrhage detection, allowing GRE to be omitted from the acute stroke protocol.

This abstract and the presentation materials are available to members only; a login is required.

Join Here