A Fast Look-Locker Imaging Technique for Quantitative Tissue Oximetry

Tissue oximetry studies using MRI can play a key role in the diagnosis, treatment, and monitoring of cancer. PISTOL is a novel oximetry technique that maps the T1 of administered HMDSO (1H reporter molecule) to obtain the tissue oxygen tension (pO2) at different locations. The aim of this study was to accelerate PISTOL acquisitions by developing a HMDSO-selective Look-Locker sequence with EPI readout. The new oximetry sequence, PISTOL-LL speeds-up 1H MR oximetry by 4X, enabling rapid pO2 mapping in under one minute. Results from in vivo studies demonstrate the successful application of the new technique in fast MR oximetry.

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