A Fast Look-Locker Imaging Technique for Quantitative Tissue Oximetry
Rohini Vidya Shankar 1 and Vikram D Kodibagkar 1
Biomedical Engineering, Arizona State
University, Tempe, AZ, United States
Tissue oximetry studies using MRI can play a key role in
the diagnosis, treatment, and monitoring of cancer.
PISTOL is a novel oximetry technique that maps the T1 of
administered HMDSO (1H reporter molecule) to obtain the
tissue oxygen tension (pO2) at different locations. The
aim of this study was to accelerate PISTOL acquisitions
by developing a HMDSO-selective Look-Locker sequence
with EPI readout. The new oximetry sequence, PISTOL-LL
speeds-up 1H MR oximetry by 4X, enabling rapid pO2
mapping in under one minute. Results from in vivo
studies demonstrate the successful application of the
new technique in fast MR oximetry.
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