Comparison of 3 He MRI and CT image-based ventilation using deformable image registration
Bilal A Tahir 1,2 , Helen Marshall 2 , Matthew Q Hatton 1 , Jim M Wild 2 , and Rob H Ireland 1,2
Academic Unit of Clinical Oncology,
University of Sheffield, Sheffield, South Yorkshire,
Unit of Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom
Image registration of inspiratory and expiratory lung CT
has been proposed to generate surrogates of ventilation.
However, validation against established ventilation
modalities is required prior to clinical implementation.
Here, we present a method using deformable image
registration, via same-breath 1H MRI, to enable ROI
correlation analysis of ventilation calculated by dual
breath-hold CT with hyperpolarized 3He MRI, which is
demonstrated in 3 patients with moderate-to-severe
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