Abstract #3812
In vivo Lactate T 1 and T 2 Relaxation Times in Preclinical Cancer Models Absolute Quantification of Tumor Lactate
Ellen Ackerstaff
1
, H. Carl LeKaye
1
,
Natalia Kruchevsky
1
, Kristen L. Zakian
1
,
Nirilanto Ramamonjisoa
1
, Ekaterina Moroz
1
,
Inna S. Serganova
1
, Ronald G. Blasberg
1
,
and Jason A. Koutcher
1
1
Memorial Sloan Kettering Cancer Center, New
York, NY, United States
Increased lactate has been associated with aggressive,
treatment-resistant tumors. To quantify
in
vivo
lactate
from MR spectra acquired using lactate-editing, knowing
in
vivo
lactate
T
1
and
T
2
relaxation
times is essential. Preclinically, accurate
in
vivo
T
1
and
T
2
values
are difficult to obtain and few are reported. We aim to
fill this void. We found similar T
1
and
T
2
values
for two prostate cancer models, which were lower than
previously reported values in other cancers. We now
expand our studies to include more tumor models for our
future research studying the role of lactate in tumor
development, progression, and treatment response.
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