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Abstract #3812

In vivo Lactate T 1 and T 2 Relaxation Times in Preclinical Cancer Models Absolute Quantification of Tumor Lactate

Ellen Ackerstaff 1 , H. Carl LeKaye 1 , Natalia Kruchevsky 1 , Kristen L. Zakian 1 , Nirilanto Ramamonjisoa 1 , Ekaterina Moroz 1 , Inna S. Serganova 1 , Ronald G. Blasberg 1 , and Jason A. Koutcher 1
1 Memorial Sloan Kettering Cancer Center, New York, NY, United States

Increased lactate has been associated with aggressive, treatment-resistant tumors. To quantify in vivo lactate from MR spectra acquired using lactate-editing, knowing in vivo lactate T 1 and T 2 relaxation times is essential. Preclinically, accurate in vivo T 1 and T 2 values are difficult to obtain and few are reported. We aim to fill this void. We found similar T 1 and T 2 values for two prostate cancer models, which were lower than previously reported values in other cancers. We now expand our studies to include more tumor models for our future research studying the role of lactate in tumor development, progression, and treatment response.

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