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Abstract #3813

Comparison of APT- and NOE-CEST in rat glioma at 7 T Potentials for tumor characterization and detection of tumor cell infiltration

Mona Salehi Ravesh 1 , Monika Huhndorf 2 , Amir Moussavi 1 , Kristin Koetz 1 , Judith Becker 1 , Kirsten Hattermann 3 , and Susann Boretius 1

1 Clinic of Radiology and Neuroradiology, Section Biomedical Imaging, Kiel, Schleswig-Holstein, Germany, 2 Department of Radiology and Neuroradiology, Schleswig-Holstein, Germany, 3 Christian-Albrechts-University of Kiel, Anatomical Institute, Schleswig-Holstein, Germany

Amide proton transfer (APT) and the Nuclear Overhauser Enhancement (NOE) have emerged as potential new imaging contrasts. Here we applied these techniques on a glioma model in rats. Maps of the magnetization transfer rate, both at -3.5 ppm and +3.5 ppm, revealed a reduction of the MTR in the tumor. NOE-CEST however revealed additional information about the tumor boundaries. Thus, NOE-CEST MRI may confer specific benefits in the detection and characterization of glioblastoma in patients.

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