Abstract #3813
Comparison of APT- and NOE-CEST in rat glioma at 7 T Potentials for tumor characterization and detection of tumor cell infiltration
Mona Salehi Ravesh 1 , Monika Huhndorf 2 , Amir Moussavi 1 , Kristin Koetz 1 , Judith Becker 1 , Kirsten Hattermann 3 , and Susann Boretius 1
1
Clinic of Radiology and Neuroradiology,
Section Biomedical Imaging, Kiel, Schleswig-Holstein,
Germany,
2
Department
of Radiology and Neuroradiology, Schleswig-Holstein,
Germany,
3
Christian-Albrechts-University
of Kiel, Anatomical Institute, Schleswig-Holstein,
Germany
Amide proton transfer (APT) and the Nuclear Overhauser
Enhancement (NOE) have emerged as potential new imaging
contrasts. Here we applied these techniques on a glioma
model in rats. Maps of the magnetization transfer rate,
both at -3.5 ppm and +3.5 ppm, revealed a reduction of
the MTR in the tumor. NOE-CEST however revealed
additional information about the tumor boundaries. Thus,
NOE-CEST MRI may confer specific benefits in the
detection and characterization of glioblastoma in
patients.
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