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Abstract #3814

cPLA2IVA inhibition in basal-like breast cancer: Reduced tumor growth with metabolic, vascular and gene expression changes

Hanna Maja Tunset 1 , Eugene Kim 1 , Jana Cebulla 1 , Muhammad Riyas Vettukattil 1 , Astrid Jullumstr Feuerherm 2 , Berit Johansen 2 , Tone Frost Bathen 1 , and Siver Andreas Moestue 1

1 MR Cancer Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 2 Avexxin AS, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway

The cPLA2IVA gene PLA2G4A is highly expressed in aggressive basal-like breast cancer (BLBC) and may be represent a new therapeutic target. 1H HR MAS MRS, CT, and gene expression analysis were used to explore the effect of cPLA2IVA inhibition in BLBC xenografts. Treatment significantly inhibited tumor growth and induced early favorable metabolic changes (higher PCho, lower GPC), intermediate anti-angiogenic effects (smaller vessels, avascular regions), and late gene expression changes (up-regulated transcription and translation, possibly apoptosis). Thus, cPLA2IVA inhibition may represent a novel strategy for targeted treatment of BLBC

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