Magnetization transfer imaging in a mouse model of orthotopic pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is still among the most devastating types of cancer characterized by infiltrative growth often with extensive fibrosis, the latter being an important predictor of poor chemotherapy response. In an orthotopic mouse model of PDAC with variable degree of fibrosis, we established and evaluated in-vivo radial imaging with magnetization transfer weighting. MT saturation correcting the MT-weighted signal for signal amplitude and T1 relaxation allowed quantification of tumor associated desmoplasia. Transfer of these methods to humans may allow individualized adjustments of chemotherapy.

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