Abstract #3816
Magnetization transfer imaging in a mouse model of orthotopic pancreatic cancer
Amir Moussavi 1 , Kristin Koetz 1 , Sanjay Tiwari 1 , and Susann Boretius 1
1
Section Biomedical Imaging, Department of
Radiology and Neuroradiology,
Christian-Albrechts-University, Kiel, Germany
Pancreatic ductal adenocarcinoma (PDAC) is still among
the most devastating types of cancer characterized by
infiltrative growth often with extensive fibrosis, the
latter being an important predictor of poor chemotherapy
response. In an orthotopic mouse model of PDAC with
variable degree of fibrosis, we established and
evaluated in-vivo radial imaging with magnetization
transfer weighting. MT saturation correcting the
MT-weighted signal for signal amplitude and T1
relaxation allowed quantification of tumor associated
desmoplasia. Transfer of these methods to humans may
allow individualized adjustments of chemotherapy.
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