Abstract #3817
In vivo Monitoring of Enzyme Activity in a Transgenic Breast Cancer Model with Hyperpolarized C-13 Metabolic Activity Decomposition MRSI
Zihan Zhu 1,2 , Peter J. Shin 1,2 , Christine Leon Swisher 3 , Peder E.Z. Larson 1,2 , Hsin-Yu Chen 1,2 , Hong Shang 1,2 , Eugene Milshteyn 1,2 , Robert A. Bok 1 , Andrei Goga 4 , and Daniel B. Vigneron 1,2
1
Department of Radiology and Biomedical
Imaging, University of California, San Francsico, San
Francisco, CA, United States,
2
UC
Berkeley-UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States,
3
Massachusetts
General Hospital and Harvard Medical School, MA, United
States,
4
Department
of Cell and Tissue Biology, University of California,
San Francsico, San Francisco, CA, United States
Molecular imaging with hyperpolarized C-13 substrates
provides valuable metabolic exchange information
non-invasively. In this work, the dynamic Metabolic
Activity Decomposition Stimulated-echo Acquisition Mode
(MAD-STEAM) sequence was applied to a switchable
oncogene-driven breast cancer mouse model. The results
showed the feasibility of using MAD-STEAM to detect
enzymatic activity changes within tumor and demonstrated
its potential to monitor tumor progression and
regression.
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