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Abstract #3817

In vivo Monitoring of Enzyme Activity in a Transgenic Breast Cancer Model with Hyperpolarized C-13 Metabolic Activity Decomposition MRSI

Zihan Zhu 1,2 , Peter J. Shin 1,2 , Christine Leon Swisher 3 , Peder E.Z. Larson 1,2 , Hsin-Yu Chen 1,2 , Hong Shang 1,2 , Eugene Milshteyn 1,2 , Robert A. Bok 1 , Andrei Goga 4 , and Daniel B. Vigneron 1,2

1 Department of Radiology and Biomedical Imaging, University of California, San Francsico, San Francisco, CA, United States, 2 UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States, 3 Massachusetts General Hospital and Harvard Medical School, MA, United States, 4 Department of Cell and Tissue Biology, University of California, San Francsico, San Francisco, CA, United States

Molecular imaging with hyperpolarized C-13 substrates provides valuable metabolic exchange information non-invasively. In this work, the dynamic Metabolic Activity Decomposition Stimulated-echo Acquisition Mode (MAD-STEAM) sequence was applied to a switchable oncogene-driven breast cancer mouse model. The results showed the feasibility of using MAD-STEAM to detect enzymatic activity changes within tumor and demonstrated its potential to monitor tumor progression and regression.

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