Abstract #3818
Multi-Parametric mpMRI to Characterize Brain and Bone Metastases in Disseminated Breast Cancer
Natalie Julie Serkova 1 , Diana M Cittelly 1 , Kendra M Huber 1 , and Carol A Sartorius 1
1
University of Colorado Anschutz Medical
Center, Aurora, Colorado, United States
Non-invasive multiparametric mpMRI of multifocal
metastatic breast cancer provides characteristic MRI
signatures for brain versus bone lesions in a mouse
model of disseminated breast cancer. Brain metastatic
phenotype is characterized by low vascularity and cell
density as revealed by low Ktrans and ADC values,
respectively. In future, quantitative mpMRI end-points
have potential to stratify patients into smart
targeted treatment regimens based on a particular tumor
radiologiocal profile.
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