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Abstract #3818

Multi-Parametric mpMRI to Characterize Brain and Bone Metastases in Disseminated Breast Cancer

Natalie Julie Serkova 1 , Diana M Cittelly 1 , Kendra M Huber 1 , and Carol A Sartorius 1

1 University of Colorado Anschutz Medical Center, Aurora, Colorado, United States

Non-invasive multiparametric mpMRI of multifocal metastatic breast cancer provides characteristic MRI signatures for brain versus bone lesions in a mouse model of disseminated breast cancer. Brain metastatic phenotype is characterized by low vascularity and cell density as revealed by low Ktrans and ADC values, respectively. In future, quantitative mpMRI end-points have potential to stratify patients into smart targeted treatment regimens based on a particular tumor radiologiocal profile.

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