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Abstract #3819

Source-based nosologic imaging of response to therapy in pre-clinical glioblastoma

Sandra Ortega-Martorell 1,2 , Ivan Olier 3 , Teresa Delgado-Goi 4 , Magdalena Ciezka 2,5 , Ana Paula Candiota 2,5 , Margarida Juli-Sap 2,5 , Mart Pumarola 2,5 , Paulo Lisboa 1 , and Carles Ars 2,5

1 Liverpool John Moores University, Liverpool, Merseyside, United Kingdom, 2 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Cerdanyola del Valls, Spain, 3 The University of Manchester, Manchester, United Kingdom, 4 The Institute of Cancer Research, London, United Kingdom, 5 Universitat Autnoma de Barcelona, Cerdanyola del Valls, Spain

A source-based extraction method is shown to produce nosological images allowing convenient non-invasive tracking of preclinical GBM response to therapy. The source-based classifier was developed from a training set of 14 C57Bl/6 mice harbouring GL261 GBM and validated in a further independent set of 24 additional mice using comparison with post-sacrifice histopathology.

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