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Abstract #3820

Evaluation of metronomic chemotherapy in a mouse model using DCE-MRI and DWI

Melanie Freed 1,2 , Kerryanne Winters 1,2 , Jin Zhang 1,2 , and Sungheon G. Kim 1,2

1 Center for Advanced Imaging Innovation and Research (CAI2R), Dept. Radiology, NYU School of Medicine, New York, NY, United States, 2 Bernard and Irene Schwartz Center for Biomedical Imaging, Dept. Radiology, NYU School of Medicine, New York, NY, United States

Metronomic chemotherapy is a promising method that delivers chemotherapy in low, frequent doses and has been shown to demonstrate superior response over traditional chemotherapy in some cases. There is a need to develop mouse models and techniques for evaluating dose and scheduling of metronomic chemotherapy to optimize its usage and benefits. In this study, we investigate the use of DCE-MRI and DWI to evaluate metronomic chemotherapy of BALB/c mice with implanted 4T1 mouse mammary tumor cells. Our data suggests this may be a good model for advanced breast cancer and that ADC values may be sensitive to early therapy response.

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